The Hong Kong-Zhuhai-Macao Bridge (Hong Kong Section) Half Marathon will be held on Sunday morning.
Around 30% of the 10,000 runners taking part are non-local participants.
The route will start from the artificial island at the bridge's Hong Kong Port.
This year also features a 10km Challenge category for the first time.
Starting Saturday afternoon, police will implement road closures at the bridge in phases.
Restrictions are expected to be fully lifted by Sunday afternoon.